Assuntos
Ectima Contagioso/patologia , Doenças das Cabras/patologia , Vírus do Orf/classificação , Doenças dos Ovinos/patologia , Animais , Anticorpos Antivirais/biossíntese , Antígenos Virais/análise , DNA Viral/análise , Ectima Contagioso/imunologia , Ectima Contagioso/virologia , Doenças das Cabras/imunologia , Doenças das Cabras/virologia , Cabras , Vírus do Orf/genética , Vírus do Orf/imunologia , Mapeamento por Restrição , Ovinos , Doenças dos Ovinos/imunologia , Doenças dos Ovinos/virologia , Pele/patologia , Pele/virologiaRESUMO
Twelve goats about 3 months of age were divided into 4 equal groups. Goats in Groups 1 and 2 were infected with orf virus followed by Corynebacterium pyogenes infection of Groups 1 and 3, 3 days after the first appearance of orf lesions. Goats in Group 4 were uninfected controls. Complicated orf lesions which consisted of wet suppurative scabs around the entire lips were observed in goats in Group 1. The lesions persisted for 24 days but were most severe from days 8 to 13. Goats in Group 2 developed lesions typical of orf virus infection that lasted 10 days, while goats in Group 3 developed small nodules of about 1 cm diameter, 48 hours following the introduction of C. pyogenes, which persisted for only 6 days. No lesion was observed in goats in Group 4. Two goats in Group 1 with complicated orf died after 16 and 22 days respectively.
Assuntos
Infecções por Corynebacterium/veterinária , Corynebacterium pyogenes , Ectima Contagioso/microbiologia , Doenças das Cabras/microbiologia , Superinfecção/veterinária , Animais , Infecções por Corynebacterium/microbiologia , Infecções por Corynebacterium/patologia , Ectima Contagioso/patologia , Doenças das Cabras/patologia , Cabras , Vírus do Orf , Superinfecção/microbiologia , Superinfecção/patologia , Fatores de TempoRESUMO
Platelet aggregation to collagen, and productions of 6-keto-prostaglandin-F1-alpha and thromboxane B2 during aggregation were measured after an overnight fast, involving both food and cigarettes, in 19 clinically healthy habitual smokers (10 or more cigarettes/day) and 23 non-smokers receiving the same diet. The subjects (all males; ages = 21-30 years) were residents of a school hostel. Mean platelet aggregation was significantly lower in smokers than non-smokers (23.2 ohms vs 31.5 ohms, p less than 0.005). Non-smokers had significantly higher mean concentration of 6-keto-prostaglandin-F1-alpha than smokers (109.8 pmol/l vs 92.3 pmol/l, p less than 0.05). The level of thromboxane B2 did not differ significantly between the two groups. These observations suggest that the role of smoking as a risk factor for ischaemic heart disease is unlikely to be related to a direct enhancement of aggregation. On the contrary, the observations seem to suggest that habitual smoking may directly reduce platelet aggregability.
Assuntos
Epoprostenol/biossíntese , Agregação Plaquetária/efeitos dos fármacos , Fumar/sangue , Tromboxano A2/biossíntese , 6-Cetoprostaglandina F1 alfa/biossíntese , Trifosfato de Adenosina/sangue , Adulto , Plaquetas/metabolismo , Dieta , Humanos , Lipídeos/sangue , Masculino , Tromboxano B2/sangue , Vitamina E/sangueRESUMO
PIP: The effect of low dose combined oral contraceptives containing 30 mcg ethinyl estradiol and either 150 mcg levonorgestrel or 150 mcg desogestrel on coagulation indices in Malaysian women was examined. 50 women who had been using the pills for 1 year or more, were compared to 75 non-users. All were attending the Maternity Clinic of the General Hospital, Kuala Lumpur. Pill users registered shorter prothrombin time, 11.5 vs. 11.1 seconds (p=0.016), and partial thromboplastin time, 40.1 vs 35.1 seconds (p=0.000). Since there were no significant differences in Factors II, V, VII, or VIII, the overall effects of low-dose pills on coagulation is probably not clinically significant.^ieng
